The use of rodent skilled reaching as a translational model for investigating brain damage and disease
Identifieur interne : 001488 ( Main/Exploration ); précédent : 001487; suivant : 001489The use of rodent skilled reaching as a translational model for investigating brain damage and disease
Auteurs : Alexander Klein [Royaume-Uni] ; Lori-Ann R. Sacrey [Canada] ; Ian Q. Whishaw [Canada] ; Stephen B. Dunnett [Royaume-Uni]Source :
- Neuroscience and biobehavioral reviews [ 0149-7634 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Neurological diseases, including Parkinson's disease, Huntington's disease, and brain damage caused by stroke, cause severe motor impairments. Deficits in hand use are one of the most debilitating motor symptoms and include impairments in body posture, forelimb movements, and finger shaping for manipulating objects. Hand movements can be formally studied using reaching tasks, including the skilled reaching task, or reach-to-eat task. For skilled reaching, a subject reaches for a small food item, grasps it with the fingers, and places it in the mouth for eating. The human movement and its associated deficits can be modeled by experimental lesions to the same systems in rodents which in turn provide an avenue for investigating treatments of human impairments. Skilled reaching movements are scored using three methods: (1) end point measures of attempts and success, (2) biometric measures, and (3) movement element rating scales derived from formal descriptions of movement. The striking similarities between human and rodent reaching movements allow the analysis of the reach-to-eat movement to serve as a powerful tool to generalize preclinical research to clinical conditions.
Affiliations:
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Dunnett</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Brain Repair Group, School of Biosciences, Cardiff University</s1><s2>Cardiff, Wales</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff, Wales</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0159173</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0159173 INIST</idno><idno type="RBID">Pascal:12-0159173</idno><idno type="wicri:Area/PascalFrancis/Corpus">000212</idno><idno type="stanalyst">FRANCIS 12-0159173 INIST</idno><idno type="wicri:Area/PascalFrancis/Corpus">000259</idno><idno type="wicri:Area/PascalFrancis/Curation">000A40</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000108</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000108</idno><idno type="wicri:doubleKey">0149-7634:2012:Klein A:the:use:of</idno><idno type="wicri:Area/Main/Merge">001522</idno><idno type="wicri:Area/Main/Curation">001488</idno><idno type="wicri:Area/Main/Exploration">001488</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The use of rodent skilled reaching as a translational model for investigating brain damage and disease</title><author><name sortKey="Klein, Alexander" sort="Klein, Alexander" uniqKey="Klein A" first="Alexander" last="Klein">Alexander Klein</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Brain Repair Group, School of Biosciences, Cardiff University</s1><s2>Cardiff, Wales</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff, Wales</wicri:noRegion></affiliation></author><author><name sortKey="Sacrey, Lori Ann R" sort="Sacrey, Lori Ann R" uniqKey="Sacrey L" first="Lori-Ann R." last="Sacrey">Lori-Ann R. Sacrey</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Canadian Centre for Behavioural Neuroscience, University of Lethbridge</s1><s2>Lethbridge, Alberta</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Lethbridge, Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Whishaw, Ian Q" sort="Whishaw, Ian Q" uniqKey="Whishaw I" first="Ian Q." last="Whishaw">Ian Q. Whishaw</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Canadian Centre for Behavioural Neuroscience, University of Lethbridge</s1><s2>Lethbridge, Alberta</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Lethbridge, Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Dunnett, Stephen B" sort="Dunnett, Stephen B" uniqKey="Dunnett S" first="Stephen B." last="Dunnett">Stephen B. Dunnett</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Brain Repair Group, School of Biosciences, Cardiff University</s1><s2>Cardiff, Wales</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff, Wales</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neuroscience and biobehavioral reviews</title><title level="j" type="abbreviated">Neurosci. biobehav. rev.</title><idno type="ISSN">0149-7634</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuroscience and biobehavioral reviews</title><title level="j" type="abbreviated">Neurosci. biobehav. rev.</title><idno type="ISSN">0149-7634</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Behavior</term><term>Cerebral disorder</term><term>Goal directed movement</term><term>Huntington disease</term><term>Models</term><term>Motor control</term><term>Motor system disorder</term><term>Motricity</term><term>Parkinson disease</term><term>Review</term><term>Rodentia</term><term>Skill</term><term>Stroke</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Habileté</term><term>Motricité</term><term>Mouvement orienté</term><term>Modèle</term><term>Pathologie de l'encéphale</term><term>Maladie de Parkinson</term><term>Chorée de Huntington</term><term>Accident cérébrovasculaire</term><term>Trouble moteur</term><term>Comportement</term><term>Article synthèse</term><term>Rodentia</term><term>Contrôle moteur</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Neurological diseases, including Parkinson's disease, Huntington's disease, and brain damage caused by stroke, cause severe motor impairments. Deficits in hand use are one of the most debilitating motor symptoms and include impairments in body posture, forelimb movements, and finger shaping for manipulating objects. Hand movements can be formally studied using reaching tasks, including the skilled reaching task, or reach-to-eat task. For skilled reaching, a subject reaches for a small food item, grasps it with the fingers, and places it in the mouth for eating. The human movement and its associated deficits can be modeled by experimental lesions to the same systems in rodents which in turn provide an avenue for investigating treatments of human impairments. Skilled reaching movements are scored using three methods: (1) end point measures of attempts and success, (2) biometric measures, and (3) movement element rating scales derived from formal descriptions of movement. The striking similarities between human and rodent reaching movements allow the analysis of the reach-to-eat movement to serve as a powerful tool to generalize preclinical research to clinical conditions.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Klein, Alexander" sort="Klein, Alexander" uniqKey="Klein A" first="Alexander" last="Klein">Alexander Klein</name></noRegion><name sortKey="Dunnett, Stephen B" sort="Dunnett, Stephen B" uniqKey="Dunnett S" first="Stephen B." last="Dunnett">Stephen B. Dunnett</name></country><country name="Canada"><noRegion><name sortKey="Sacrey, Lori Ann R" sort="Sacrey, Lori Ann R" uniqKey="Sacrey L" first="Lori-Ann R." last="Sacrey">Lori-Ann R. Sacrey</name></noRegion><name sortKey="Whishaw, Ian Q" sort="Whishaw, Ian Q" uniqKey="Whishaw I" first="Ian Q." last="Whishaw">Ian Q. 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